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Guinea pig antiserum produced via inactivated 146S antigens of foot and mouth disease virus is acceptable for routine use in complement fixation typing tests.
Summary : Guinea pig antiserum production following administration of inactivated foot and mouth disease virus 146S antigens was found to be acceptable for routine use in the complement fixation typing test, within defined criteria. The specificity of antisera after the single or repeated inoculation regimes was strain dependent, probably reflecting a variation in antigenic stability. Antisera with a narrow intra-typic res ponse were shown to be usable in the typing test by making mixtures.
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Ferris et al. (1984) studied this question.
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