Why the study?
Does vaccination with cyanogen bromide-peptides of VP3 of foot-and-mouth disease virus induce neutralizing antibodies and immunity in guinea pigs?
Population
Guinea pigs
Comparison
Cyanogen bromide-cleaved peptides of the virus… vs Purified 146S particles (native virus particles)
Design
Preclinical
Authors
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Supports VP3 peptide exploration for FMDV vaccines in animals; leaves open translation to livestock or field use.
Does vaccination with cyanogen bromide-peptides of VP3 of foot-and-mouth disease virus induce neutralizing antibodies and immunity in guinea pigs?
Cleavage peptides of the VP3 capsid protein of foot-and-mouth disease virus retain some immunological determinants capable of inducing neutralizing antibodies in guinea pigs, despite a lower immune response compared to native virus particles.
Kaaden et al. (1977) studied this question.
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