Key result
Intranasal immunization of guinea pigs with a foot-and-mouth disease virus peptide conjugate without adjuvant provided full protection against homotypic virus challenge in 86% of animals.
Why the study?
Does intranasal immunization with a foot-and-mouth disease virus peptide conjugate induce antibodies and protection against challenge in guinea pigs?
Population
Guinea pigs
Design
Preclinical
Authors
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Adjuvant-free intranasal peptide vaccination shows promise in guinea pigs; leaves open translation to livestock or other species.
Does intranasal immunization with a foot-and-mouth disease virus peptide conjugate induce antibodies and protection against challenge in guinea pigs?
Intranasal inoculation with a foot-and-mouth disease virus peptide conjugate without adjuvant offers a potential route of vaccination to elicit protection in the upper respiratory tracts of susceptible animals.
Fischer et al. (2003) studied Foot-and-mouth disease. Intranasal immunization with a keyhole limpet hemocyanin-linked peptide vs. Peptide conjugates plus mucosal adjuvant cholera toxin was evaluated on Protection upon challenge with homotypic virus. Intranasal immunization of guinea pigs with a foot-and-mouth disease virus peptide conjugate without adjuvant provided full protection against homotypic virus challenge in 86% of animals.