November 1, 1985Journal of General Virology

Immunological Priming with Synthetic Peptides of Foot-and-Mouth Disease Virus

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Population

Guinea-pigs

Comparison

Sub-immunizing dose of synthetic peptide coupled… vs Absence of adjuvant

Design

Preclinical

Follow-up

42 days between priming and booster

Authors

MFMichael J. FrancisWatford General Hospital CFCarrie FryFrontier Science & Technology Research Foundation DRDavid J. RowlandsUniversity of Leeds

Discussion

Member takes

Implication

Supports peptide priming strategies in FMDV models; leaves open translation to livestock or clinical use.

Structured PICO

Population

Guinea-pigs

Intervention

Sub-immunizing dose of synthetic peptide (amino acids 141-160 of protein VP1 from FMDV, serotype O1) coupled to keyhole limpet haemocyanin (141-160KLH) or uncoupled/liposomes, with adjuvant, followed by a booster dose

Comparator

Absence of adjuvant

Outcome

FMDV serotype-specific neutralizing antibody responsesurrogate

The 141-160 peptide of FMDV can initiate its own T-helper cell response and prime for a neutralizing antibody response when administered with an adjuvant.

Cite This Study

Francis et al. (1985) studied this question.

synapsesocial.com/papers/6a8b08ae3fd21775a53387fb https://doi.org/10.1099/0022-1317-66-11-2347

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Immunological Priming with Synthetic Peptides of Foot-and-Mouth Disease Virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Immunological Priming with Synthetic Peptides of Foot-and-Mouth Disease Virus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider