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April 1, 1964The Journal of Immunology

Characterization of Antibodies Produced by Guinea Pigs Inoculated with Inactivated Foot-and-Mouth Disease Antigen

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Population

Guinea pigs

Design

Preclinical

Follow-up

in excess of 30 days

Authors

JGJ. H. GravesThe Pirbright InstituteKCK. M. CowanKenya Agricultural Research InstituteRTRodes TrautmanThe University of Western Australia

Discussion

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Implication

Antibody class transition in this guinea pig model precludes early quantitative assays; leaves open assay standardization for FMDV vaccine research.

Structured PICO

P
Population
Guinea pigs
I
Intervention
Inoculation with inactivated foot-and-mouth disease antigen
O
Outcome
Characterization of neutralizing antibodies (physical-chemical and complement-fixing properties)surrogate

Guinea pigs inoculated with inactivated foot-and-mouth disease virus produce two distinct types of neutralizing antibodies over time, precluding quantitative assays during the first three weeks.

Cite This Study

Graves et al. (1964) studied this question.

synapsesocial.com/papers/6a6f5645ac440176ef28078bhttps://doi.org/10.4049/jimmunol.92.4.501
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Antibodies Produced by Guinea Pigs Infected with Foot-and-Mouth Disease Virus1965 · 39 citations
  2. 2A Study of the Antibodies in Guinea Pigs Infected with Foot-and-Mouth Disease Virus1962 · 11 citations
  3. 3A β-Globulin Antibody in the Sera of Guinea Pigs and Cattle Infected with Foot-and-Mouth Disease1960 · 15 citations
  4. 4Immunochemical Studies of Foot-and-Mouth Disease1971 · 9 citations
  5. 5Nature of the Antibody Response to the Foot-and-Mouth Disease Virus Particle, its 12S Protein Subunit and the Isolated Immunizing Polypeptide VP11982 · 27 citations