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September 1, 1964The Journal of Immunology

Further Studies of the Early Antibody in the Sera of Cattle and Guinea Pigs Infected with Foot-and-Mouth Disease Virus

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Population

Cattle and guinea pigs infected with foot-and-mouth disease virus

Design

Preclinical

Authors

FBF. BrownMaryland Institute College of ArtBCB. CartwrightBellevue CollegeJNJoseph NewmanUniversity of Kansas Medical Center

Discussion

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Implication

Offers no immediate clinical application; leaves open generalization of 19S antibody properties beyond this animal model.

Structured PICO

P
Population
Cattle and guinea pigs infected with foot-and-mouth disease virus
I
Intervention
Reaction of early antibody with mercaptoethanol
O
Outcome
Neutralizing and precipitating properties of the antibodysurrogate

The early antibody produced in cattle and guinea pigs against foot-and-mouth disease virus is a 19S γ-globulin whose neutralizing and precipitating properties are destroyed by mercaptoethanol.

Cite This Study

Brown et al. (1964) studied this question.

synapsesocial.com/papers/6a86d7b3854ced5b0ecf7b66https://doi.org/10.4049/jimmunol.93.3.397
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1A β-Globulin Antibody in the Sera of Guinea Pigs and Cattle Infected with Foot-and-Mouth Disease1960 · 15 citations
  2. 2Antibodies Produced by Guinea Pigs Infected with Foot-and-Mouth Disease Virus1965 · 39 citations
  3. 3Characterization of Antibodies Produced by Guinea Pigs Inoculated with Inactivated Foot-and-Mouth Disease Antigen1964 · 29 citations
  4. 4Immunochemical Studies of Foot-and-Mouth Disease1971 · 9 citations
  5. 5A Study of the Antibodies in Guinea Pigs Infected with Foot-and-Mouth Disease Virus1962 · 11 citations