Why the study?
Does intraoral inoculation with the small plaque virus of FMDV O/JPN/2000 cause clinical disease and typical lesions in pigs?
Population
6 pigs (4 weeks old) experimentally infected with FMDV O/JPN/2000, plus 1 non-infected control pig
Comparison
Intraoral inoculation with 1 ml of 10^6… vs Non-infected control pig (n=1)
Design
Preclinical
Follow-up
up to 6 days post inoculation
Authors
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Attenuated FMDV shows no lesions in pigs; leaves open molecular determinants and vaccine potential for validation.
Does intraoral inoculation with the small plaque virus of FMDV O/JPN/2000 cause clinical disease and typical lesions in pigs?
The small plaque variant of FMDV O/JPN/2000 exhibits low pathogenicity in pigs, providing an experimental model for studying FMDV attenuation.
Yamada et al. (2018) studied this question.
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