January 1, 2008Journal of Veterinary Medical ScienceOpen Access

Comparison of the Characters of the Plaque-Purified Viruses from Foot-and-Mouth Disease Virus O/JPN/2000

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Population

Primary bovine kidney (BK) cells, IBRS-2 cells, and 3-to-5-day-old BALB/c suckling mice

Comparison

Infection with small plaque virus or large… vs Comparison between SPV and LPV

Design

Preclinical

Follow-up

1 week (for suckling mice observation)

Authors

KMKazuki MoriokaNational Agriculture and Food Research Organization KFKatsuhiko FukaiNational Agriculture and Food Research Organization SOSeiichi OhashiNihon University

Discussion

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Implication

May explain mild FMDV pathogenicity in cattle; leaves open whether VP2/VP3 substitutions drive virulence in natural hosts.

Structured PICO

Population

Primary bovine kidney (BK) cells, IBRS-2 cells, and 3-to-5-day-old BALB/c suckling mice

Intervention

Infection with small plaque virus (SPV) or large plaque virus (LPV) derived from Foot-and-Mouth Disease Virus (FMDV) O/JPN/2000

Comparator

Comparison between SPV and LPV

Outcome

Pathogenicity in suckling mice (LD50), plaque phenotype, and amino acid sequence of capsid coding region

The presence of a low-virulence small plaque variant at the early passage stage may explain the mild pathogenicity of the FMDV O/JPN/2000 strain in infected cattle.

Cite This Study

Morioka et al. (2008) studied this question.

synapsesocial.com/papers/6a82396947f72330e2ffb59d https://doi.org/10.1292/jvms.70.653

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Comparison of the Characters of the Plaque-Purified Viruses from Foot-and-Mouth Disease Virus O/JPN/2000

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Comparison of the Characters of the Plaque-Purified Viruses from Foot-and-Mouth Disease Virus O/JPN/2000

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider