Why the study?
Does serial passage of foot-and-mouth disease virus in partly immunized cattle lead to the emergence of antigenically distinct variant strains?
Population
Cattle partly immunized with inactivated formol-treated vaccine of foot-and-mouth disease virus type O
Comparison
Serial passage of FMD virus type O vs Original FMD virus strain (Israel 1/63)
Design
Preclinical
Authors
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Partial immunity may drive FMDV antigenic variants in cattle; leaves open field relevance and vaccine implications.
Does serial passage of foot-and-mouth disease virus in partly immunized cattle lead to the emergence of antigenically distinct variant strains?
Serial passage of foot-and-mouth disease virus in partly immunized cattle leads to the rapid emergence of antigenically distinct variant strains capable of reinfecting recently recovered animals.
Fagg et al. (1966) studied this question.
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