In vitro antigenic testing can identify foot-and-mouth disease virus variants capable of causing disease in vaccinated cattle based on R values and neutralizing antibody differences.
Answers are grounded in this paper and cite their sources.
In vitro R-value testing may aid FMDV strain selection for cattle vaccines; hypothesis-generating and requires validation beyond this animal model.
Foot-and-mouth disease virus isolates of types O, A and SAT 2, from diseased animals in herds routinely vaccinated twice a year were compared antigenically with the vaccine strains in the complement-fixation, neutralization and radial immunodiffusion tests. It was found that strains which had readily infected vaccinated cattle had R values against the vaccine strain in the complementfixation and radial immunodiffusion tests of 30 or less, while strains causing primary outbreaks with little spread had R values of 30-40. Threefold differences in humoral neutralizing antibody concentration between the field variant and the vaccine strain in sera from vaccinated animals were likely to be significant in terms of protection.
No takes yet. Share an insight, caveat, or question.
Anderson et al. (1978) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: