Key result
A foot and mouth disease virus type A field strain showed wide antigenic divergence from the vaccine virus, resulting in a lack of cross-protection in primo-vaccinated cattle.
A field strain of foot and mouth disease virus type A showed significant antigenic divergence from the vaccine strain, leading to vaccine breakdown in cattle.
May signal FMD vaccine mismatch risk in cattle; leaves open need for updated strain validation in field trials.
Summary: A foot and mouth disease virus type A strain, isolated from an out break in a vaccinated herd, was compared serologically with the vaccine virus by the two-dimensional microneutralisation test and immunologically through a cross-immunity test in cattle. The antigenic diversity of the field virus from the vaccine virus as revealed by serological analysis was substantiated by lack of cross-protect ion in primo-vaccinated animals. The anamnestic response con sequent to infection was compared with that obtained through booster vaccination in terms of antibody levels and heterologous immunity. It was observed that anamnestic response had little effect on heterologous neutralisa tion, owing to the wide antigenic divergence.
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BELWAL et al. (1987) studied Foot and mouth disease. Field virus infection vs. Vaccine virus was evaluated on Cross-protection and anamnestic response. A foot and mouth disease virus type A field strain showed wide antigenic divergence from the vaccine virus, resulting in a lack of cross-protection in primo-vaccinated cattle.
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