September 1, 1965Journal of HygieneOpen Access

Isolation of variants during passage of a strain of foot-and-mouth disease virus in partly immunized cattle

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Population

Devon or Devon-cross steers, about 18 months old, partly immunized with formol-treated vaccine of the…

Design

Preclinical

Authors

NHN. St. G. HyslopThe Pirbright Institute RFR. H. FaggFreeman Hospital

Discussion

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Implication

Subtype variants after serial passage may enable FMDV reinfection in cattle; leaves open relevance to natural outbreaks or vaccine updates.

Structured PICO

Population

Devon or Devon-cross steers, about 18 months old, partly immunized with formol-treated vaccine of the homologous strain (Turkey 323/62)

Intervention

Serial passage (34 times) of Foot-and-mouth disease virus of Type SAT 1 (strain Turkey 323/62)

Outcome

Development of variant strains (subtype variation) assessed by complement-fixing properties and sensitivity to antiserumsurrogate

Serial passage of foot-and-mouth disease virus in partly immunized cattle leads to the emergence of immunologically distinct subtype variants capable of reinfecting previously immune animals.

Cite This Study

Hyslop et al. (1965) studied this question.

synapsesocial.com/papers/6a7628464b4bbb4785fbe1ec https://doi.org/10.1017/s0022172400045241

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Implication

Subtype variants after serial passage may enable FMDV reinfection in cattle; leaves open relevance to natural outbreaks or vaccine updates.

Isolation of variants during passage of a strain of foot-and-mouth disease virus in partly immunized cattle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Isolation of variants during passage of a strain of foot-and-mouth disease virus in partly immunized cattle

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider