Population
Foot-and-mouth disease virus type A5 variants and wild-type parental virus in cell culture
Comparison
Serial passage in cell culture and coinfection… vs Wild-type virus or comparison between variants
Design
Preclinical
Follow-up
Up to 30 passages
Authors
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Conformational epitope variants may lose resistance faster than linear in FMDV culture; leaves open relevance to in vivo persistence or escape.
In cell culture, FMDV variants based on continuous epitopes appear more stable than those based on conformational epitopes, though wild-type virus ultimately prevails.
González‐Santos et al. (1991) studied this question.
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