Population
Two foot-and-mouth disease virus mutants resistant to a neutralizing monoclonal antibody in BHK-21 cells
Comparison
Repeated replication of the mutants alone vs Passaged in competition with their parental FMDV
Design
Preclinical
Authors
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May inform FMDV passage and escape monitoring; leaves open relevance to human pathogens or interventions.
Variants previously kept at low frequency in a viral quasispecies can rapidly become the master sequence and dominate the population upon repeated replication.
Martı́nez et al. (1991) studied this question.
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