December 1, 1998Journal of VirologyOpen Access

Rapid Selection in Modified BHK-21 Cells of a Foot-and-Mouth Disease Virus Variant Showing Alterations in Cell Tropism

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Population

Partially resistant BHK-21 cells (BHK-Rb cells)

Design

Preclinical

Follow-up

6 to 10 days postinfection

Authors

Discussion

Cell culture passage may select virulent FMDV variants; hypothesis-generating for viral adaptation and requires in vivo validation.

Population

Partially resistant BHK-21 cells (BHK-Rb cells)

Intervention

Infection with foot-and-mouth disease virus (FMDV) C3Arg/85

Outcome

Selection of mutant FMDVs (C3-Rb) with altered cell tropism, increased virulence, and specific amino acid substitutions

Infection of partially permissive cells can promote the rapid selection of virus variants with altered cell tropism and increased virulence.

Escarmı́s et al. (1998) studied this question.

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