Population
Cloned BHK-21 cells persistently infected with foot-and-mouth disease virus (FMDV)
Comparison
Serial passage and viral/cellular coevolution vs Parental BHK-21 cells and parental FMDV C-S8c1
Design
Preclinical
Authors
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Supports host-virus coevolution in FMDV persistence in vitro; leaves open relevance to in vivo dynamics or therapeutic targets.
Demonstrates that coevolution of host cells and virus contributes to the maintenance of persistent viral infections in cell culture.
Torre et al. (1988) studied this question.
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