Key result
Mutant frequencies at RNA regions encoding antigenic sites C and D of foot-and-mouth disease virus were more than twentyfold lower than for antigenic site A in the absence of immune selection.
The degree of tolerance to acceptance of amino acid replacements may modulate the variation at different antigenic epitopes of the same virus, even in the absence of immune selection.
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Site-specific mutational tolerance may shape FMDV epitope variation; leaves open implications for vaccine strain selection in livestock.
Domingo et al. (1997) studied Foot-and-mouth disease virus. Serial passage in cell culture in the absence of immune selection was evaluated on Mutant frequencies at RNA regions encoding antigenic sites. Mutant frequencies at RNA regions encoding antigenic sites C and D of foot-and-mouth disease virus were more than twentyfold lower than for antigenic site A in the absence of immune selection.