Key result
Serial passage of foot-and-mouth disease virus in cell culture without antibodies led to an increase in antigenic variants from less than 10(-2) to between 0.1 and 1.
Population
Foot-and-mouth disease virus (FMDV) of serotype C (isolate C-S8c1) in cell culture
Comparison
Serial passage in cell culture in the absence of… vs Initial plaque-purified FMDV C-S8c1 preparation
Design
Preclinical
Authors
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May inform FMDV vaccine development; leaves open whether antibody-independent variation drives diversification during natural infections.
Antigenic variants of FMDV can be selected during serial passage in cell culture even in the absence of antibodies, suggesting mechanisms for antigenic diversification of RNA viruses.
Díez et al. (1989) studied Foot-and-mouth disease virus (FMDV). Serial passage in cell culture in the absence of anti-FMDV antibodies vs. Initial plaque-purified FMDV C-S8c1 preparation was evaluated on Proportion of antigenic variants. Serial passage of foot-and-mouth disease virus in cell culture without antibodies led to an increase in antigenic variants from less than 10(-2) to between 0.1 and 1.
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