Key result
Vaccination against foot-and-mouth disease virus in cattle significantly reduced viral population diversity during infection, with lower mean coding region entropy (0.0120 vs 0.0171, p<0.001).
Why the study?
The behavior of foot-and-mouth disease virus quasispecies over the full course of infection in a natural host species had not been described in detail.
Population
Vaccinated and non-vaccinated cattle experimentally infected with FMDV A24-Cruzeiro
Comparison
Vaccinated vs non-vaccinated cattle
Design
Experimental infection study with deep-sequencing analysis
Follow-up
Up to 35 days post experimental infection
Authors
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May inform FMDV vaccine strategies in livestock; leaves open translation to field control or transmission.
Absolute Event Rate: 0.012% vs 0.0171%
p-value: p=<0.001
Vaccination against FMDV in cattle induces early population bottlenecks that significantly reduce viral diversity during subclinical infection compared to non-vaccinated animals.
Fish et al. (2019) studied Foot-and-mouth disease virus (FMDV) infection (n=20). FMDV vaccination vs. Non-vaccinated was evaluated on Shannon entropy of the FMDV coding region (CDS) (p=<0.001). Vaccination against foot-and-mouth disease virus in cattle significantly reduced viral population diversity during infection, with lower mean coding region entropy (0.0120 vs 0.0171, p<0.001).
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