Why the study?
Extensive viral diversity and rapid mutation of foot-and-mouth disease virus hinder control and eradication, prompting investigation into mechanisms driving within-host evolution in cattle.
Population
Vaccinated and non-vaccinated cattle
Comparison
Vaccinated vs non-vaccinated cattle infected with FMDV
Design
Controlled experimental study
Follow-up
Up to 35 days
Authors
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May inform FMDV sampling strategies in livestock; leaves open translation to field molecular epidemiology.
Within-host evolution of FMDV in cattle occurs through both the emergence of pre-existing minority haplotypes and continuous point mutations, impacting virus sampling and molecular epidemiology.
Arzt et al. (2019) studied this question.
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