Key result
Serial superinfection of cattle with two distinct serotypes of foot-and-mouth disease virus led to the rapid generation of recombinant viruses in the upper respiratory tract within 48 hours.
Why the study?
Although recombinant foot-and-mouth disease viruses have been identified in field samples, the mechanisms of emergence of those viruses have never been elucidated.
Population
Cattle
Comparison
Serial infection with two distinct serotypes of foot-and-mouth disease virus
Authors
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Serial co-infection may drive recombinant FMDV emergence in cattle; hypothesis-generating for field surveillance and requires validation.
Stenfeldt et al. (2023) studied Foot-and-mouth disease virus (FMDV) coinfection (n=12). Simultaneous or serial exposure to two distinct strains of FMDV vs. Simultaneous vs serial exposure was evaluated on Detection of interserotypic recombinant FMDV genomes. Serial superinfection of cattle with two distinct serotypes of foot-and-mouth disease virus led to the rapid generation of recombinant viruses in the upper respiratory tract within 48 hours.
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