What is the clinical evidence from this study?

Study design: Observational. Population: Foot-and-mouth disease virus (FMDV) infection (n=8). Intervention: Co-infection of two viral swarms. Primary outcome: Recombination events.

April 25, 2018VirusesOpen Access

Within-Host Recombination in the Foot-and-Mouth Disease Virus Genome

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Key result

Analysis of 8 buffalo host samples revealed more than 15 FMDV recombination events unequally distributed across the genome, suggesting a mismatch with long-term selection pressures.

Authors

LFLuca FerrettiUniversity of Oxford ANAntonello Di NardoThe Pirbright Institute BSBenjamin J. SingerUniversity of California, Berkeley

Discussion

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Implication

Limited buffalo FMDV data supports expanded genomic surveillance; leaves open recombination's role in viral adaptation.

Study Design

Type

Observational (n=8)

PICO

Population

8 samples from buffalo hosts co-infected with two FMDV viral swarms analyzed for within-host recombination events.

Exposure / Comparator

Co-infection of two viral swarms

Primary Outcome

Recombination events

Limitations

Detection of recombination among viruses evolving at the within-host level is challenging due to the similarity of the sequences and the limitations in differentiating recombination from point mutations.

Cite This Study

Ferretti et al. (2018) conducted an observational in Foot-and-mouth disease virus (FMDV) infection (n=8). Co-infection of two viral swarms was evaluated on Recombination events. Analysis of 8 buffalo host samples revealed more than 15 FMDV recombination events unequally distributed across the genome, suggesting a mismatch with long-term selection pressures.

synapsesocial.com/papers/6a62c2303c4f8a4b5b07db33 https://doi.org/10.3390/v10050221

View Full Paper

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Bookmark

Within-Host Recombination in the Foot-and-Mouth Disease Virus Genome

Discussion

Member takes

Implication

Study Design

PICO

Limitations

Cite This Study

Within-Host Recombination in the Foot-and-Mouth Disease Virus Genome

Discussion

Member takes

Implication

Study Design

PICO

Limitations

Cite This Study

Also Consider

Also Consider