Key result
In African buffaloes co-infected with closely related FMDV strains, the effective recombination rate in the VP1 capsid gene during acute infection was approximately 0.1 per base per year.
Why the study?
Recombination is considered a minor determinant of foot-and-mouth disease virus sequence diversity, prompting an estimation of within-host recombination rates in a natural host.
Effect estimate: 0.1 per base per year
During FMDV co-infections by closely related strains, capsid-coding genes recombine within the host at a much higher rate than expected, indicating recombination and epistasis play a major role in the virus's molecular evolution.
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Within-host FMDV recombination is pervasive; challenges view as minor determinant and leaves open its role in sequence diversity.
Ferretti et al. (2020) studied Foot-and-mouth disease virus (FMDV) infection (n=3). FMDV SAT-1 inoculation was evaluated on Effective recombination rate in VP1 during the acute infection phase (0.1 per base per year). In African buffaloes co-infected with closely related FMDV strains, the effective recombination rate in the VP1 capsid gene during acute infection was approximately 0.1 per base per year.
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