February 7, 2013PLoS PathogensOpen Access

Identification and Manipulation of the Molecular Determinants Influencing Poliovirus Recombination

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Population

Poliovirus 1 coding region

Design

Preclinical

Authors

CRCharles RunckelHoward Hughes Medical Institute OWOscar WestessonGuardant (United States)RARaul AndinoLawrence Livermore National Laboratory

Discussion

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Implication

Recombination hotspots mapped in poliovirus; leaves open whether genome redesign can yield stable live vaccine strains.

Structured PICO

Population

Poliovirus 1 coding region

Intervention

Gene synthesis and deep sequencing to create a recombination map and generate an artificial hotspot

Outcome

Recombination breakpoints and hotspots

Identification of molecular determinants of poliovirus recombination suggests that whole genome re-designs could enable the development of recombination-deficient, genetically stable live vaccine strains.

Cite This Study

Runckel et al. (2013) studied this question.

synapsesocial.com/papers/6a8c07780c58d86fb4caeedc https://doi.org/10.1371/journal.ppat.1003164

View Full Paper

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Identification and Manipulation of the Molecular Determinants Influencing Poliovirus Recombination

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Identification and Manipulation of the Molecular Determinants Influencing Poliovirus Recombination

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider