Population
Cell-free system using HeLa cell extracts and SK-N-MC cells, with genetically marked poliovirus RNAs (PV1gs…
Comparison
Co-incubation of genetically marked poliovirus… vs Incubation of individual parental RNAs alone or…
Design
Preclinical
Authors
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Cell-free recombination assay enables mechanistic studies of RNA virus evolution; leaves open relevance to cellular infection and in vivo dynamics.
Genetic recombination of poliovirus can occur in a cell-free system, offering a new method to study RNA virus recombination and evolution.
Duggal et al. (1997) studied this question.
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