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April 1, 1980Journal of VirologyOpen Access

Temperature-sensitive mutants of foot-and-mouth disease virus with altered structural polypeptides. II. Comparison of recombination and biochemical maps

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Population

Temperature-sensitive mutants of foot-and-mouth disease virus and wild type

Comparison

Digestion of structural polypeptides with… vs Wild type foot-and-mouth disease virus

Design

Preclinical

Authors

AKAndrew M. Q. KingThe Pirbright InstituteWSW. R. SladeThe Pirbright InstituteJNJohn W. NewmanWestern Human Nutrition Research Center

Discussion

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Overview

Links FMDV coat protein mutations to temperature sensitivity in animal models; hypothesis-generating for viral attenuation studies.

Structured PICO

P
Population
Temperature-sensitive mutants of foot-and-mouth disease virus and wild type
I
Intervention
Digestion of structural polypeptides with Staphylococcus aureus V8 protease in the presence of sodium dodecyl sulfate and analysis by electrofocusing
C
Comparator
Wild type foot-and-mouth disease virus
O
Outcome
Protease-resistant peptide profiles and charge shiftssurrogate

The study maps the structural polypeptides of foot-and-mouth disease virus mutants, linking specific coat protein mutations to temperature sensitivity.

Cite This Study

King et al. (1980) studied this question.

synapsesocial.com/papers/6a82f495ff6798fd267d55f2https://doi.org/10.1128/jvi.34.1.67-72.1980
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1The Location of the Poly(C) Tract in the RNA of Foot-and-Mouth Disease Virus1976 · 35 citations
  2. 2Temperature-sensitive mutants of foot-and-mouth disease virus with altered structural polypeptides. I. Identification by electrofocusing1980 · 43 citations
  3. 3An Extended Genetic Recombination Map for Foot-and-Mouth Disease Virus1977 · 48 citations
  4. 4Temperature-sensitive Mutants of Foot-and-Mouth Disease Virus: the Isolation of Mutants and Observations on their Properties and Genetic Recombination1975 · 22 citations
  5. 5A Re-appraisal of the Biochemical Map of Foot-and-mouth Disease Virus RNA1978 · 43 citations