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April 1, 1980Journal of VirologyOpen Access

Temperature-sensitive mutants of foot-and-mouth disease virus with altered structural polypeptides. I. Identification by electrofocusing

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Population

Foot-and-mouth disease virus (73 temperature-sensitive mutants)

Design

Preclinical

Authors

AKAndrew M. Q. KingThe Pirbright InstituteJNJohn W. NewmanWestern Human Nutrition Research Center

Discussion

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Overview

No immediate clinical implications for FMDV; leaves open further mapping of ts mutations via electrofocusing.

Structured PICO

P
Population
Foot-and-mouth disease virus (73 temperature-sensitive mutants)
I
Intervention
Electrofocusing in polyacrylamide gel containing 9 M urea, protease treatment, carbamylation, and succinylation
O
Outcome
Identification of structural polypeptides and detection of charge changes in mutants

Electrofocusing can effectively identify structural polypeptides of foot-and-mouth disease virus and detect charge-altering amino acid substitutions in temperature-sensitive mutants.

Cite This Study

King et al. (1980) studied this question.

synapsesocial.com/papers/6a82134305dcafdeefd243d7https://doi.org/10.1128/jvi.34.1.59-66.1980
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Temperature-sensitive mutants of foot-and-mouth disease virus with altered structural polypeptides. II. Comparison of recombination and biochemical maps1980 · 31 citations
  2. 2Immunogenic and Cell Attachment Sites of FMDV: Further Evidence for their Location in a Single Capsid Polypeptide1977 · 52 citations
  3. 3Biochemical Mapping of the Foot-and-Mouth Disease Virus Genome1977 · 48 citations
  4. 4A Model for Foot-and-Mouth Disease Virus1972 · 42 citations
  5. 5Proteins Induced in BHK Cells by Infection with Foot-and-Mouth Disease Virus1975 · 12 citations