Biochemical Aspects of Variation in Foot-and-Mouth Disease Virus

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Population

Three isolates of foot-and-mouth disease virus (two serotype A, one serotype O)

Design

Preclinical

Authors

Discussion

Structural protein loci predominate in FMDV variation; leaves open whether this guides vaccine strain selection.

Population

Three isolates of foot-and-mouth disease virus (two serotype A, one serotype O)

Intervention

Biochemical analysis (RNA hybridization, ribonuclease T1 mapping, tryptic peptide analysis, PAGE analysis)

Outcome

Biochemical differences in RNA and proteins among the isolates

The major biochemical variation between foot-and-mouth disease virus isolates occurs in the genome region coding for structural proteins.

Robson et al. (1980) studied this question.

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