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May 1, 1985Proceedings of the National Academy of SciencesOpen Access

Sequence variation in the gene for the immunogenic capsid protein VP1 of foot-and-mouth disease virus type A.

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Population

Cloned cDNA genes coding for the foot-and-mouth disease virus immunogenic capsid protein, VP1, from eight…

Design

Preclinical

Authors

GWGregory N. WeddellDYDaniel G. YansuraDDDonald Dowbenko

Discussion

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Overview

May guide FMDV vaccine epitope selection; hypothesis-generating and requires functional validation before translational use.

Structured PICO

P
Population
Cloned cDNA genes coding for the foot-and-mouth disease virus (FMDV) immunogenic capsid protein, VP1, from eight different A subtypes (A5 Westerwald/58, A12 119ab, A22 550 USSR/65, A24 Cruzeiro Brazil/55, A27 Cundinamarca Colombia/76, A32 Venezuela/70, A Venceslau Brazil/76, and A Argentina/79)
I
Intervention
Nucleotide sequence determination and comparison
O
Outcome
Nucleotide sequence variations among different A subtypes

Sequence variations in the VP1 gene of FMDV type A subtypes reveal highly variable regions corresponding to immunogenic sites, potentially driven by secondary RNA structures and selective pressures.

Cite This Study

Weddell et al. (1985) studied this question.

synapsesocial.com/papers/6a8fe5d4e379aceceb3d9e90https://doi.org/10.1073/pnas.82.9.2618
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparison of the major antigenic determinants of different serotypes of foot-and-mouth disease virus1983 · 71 citations
  2. 2Comparison of the amino acid sequence of the major immunogen from three serotypes of foot and mouth disease virus1982 · 87 citations
  3. 3Nucleotide sequence and corresponding amino acid sequence of the gene for the major antigen of foot and mouth disease virus1981 · 89 citations
  4. 4Three Strains of European Foot-and-Mouth Disease Virus are Highly Conserved in the 3'-Termini and Highly Variable in the Genes of Two Capsid Proteins1982 · 6 citations
  5. 5Identification of an exposed region of the immunogenic capsid polypeptide VP1 on foot-and-mouth disease virus1983 · 45 citations