Sequencing of the VP1 region of three FMDV serotypes identified specific variable, hydrophilic regions that are likely the major immunogenic sites of the virus.
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Candidate epitopes may guide FMDV vaccine design; leaves open in vivo protection and cross-serotype validation.
Cloned cDNA molecules from three serotypes of FMDV have been sequenced around the VP1-coding region. The predicted amino acid sequences for VP1 were compared with the published sequences and variable regions identified. The amino acid sequences were also analysed for hydrophilic regions. Two of the variable regions, numbered 129-160 and 193-204 overlapped hydrophilic regions, and were therefore identified as potentially immunogenic. These regions overlap regions shown by others to be immunogenic.
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Makoff et al. (1982) studied this question.
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