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January 1, 1982Nucleic Acids ResearchOpen Access

Comparison of the amino acid sequence of the major immunogen from three serotypes of foot and mouth disease virus

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Population

Cloned cDNA molecules from three serotypes of foot and mouth disease virus: A24Cruzeiro, C3Indaial, and O1BFS

Comparison

DNA sequencing of the VP1-coding region and… vs Published sequences of A1061, A12119, and O1K…

Design

Preclinical

Authors

AMAndrew MakoffCPCora A. PaynterDRDavid J. Rowlands

Discussion

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Overview

Candidate epitopes may guide FMDV vaccine design; leaves open in vivo protection and cross-serotype validation.

Structured PICO

P
Population
Cloned cDNA molecules from three serotypes of foot and mouth disease virus (FMDV): A24Cruzeiro, C3Indaial, and O1BFS
I
Intervention
DNA sequencing of the VP1-coding region and hydrophilicity analysis
C
Comparator
Published sequences of A1061, A12119, and O1K strains
O
Outcome
Predicted amino acid sequences, variable regions, and hydrophilic regions of VP1

Sequencing of the VP1 region of three FMDV serotypes identified specific variable, hydrophilic regions that are likely the major immunogenic sites of the virus.

Cite This Study

Makoff et al. (1982) studied this question.

synapsesocial.com/papers/6a746cddf5fc39414403235chttps://doi.org/10.1093/nar/10.24.8285
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  1. 1Nucleotide sequence and corresponding amino acid sequence of the gene for the major antigen of foot and mouth disease virus1981 · 89 citations
  2. 2Cloned Viral Protein Vaccine for Foot-and-Mouth Disease: Responses in Cattle and Swine1981 · 501 citations
  3. 3Further Evidence for Multiple Proteins in the Foot-and-Mouth Disease Virus Particle1971 · 67 citations
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