Key result
In-silico analysis of 47 FMDV serotype Asia1 VP1 sequences identified five antigenic peptides as the least variable epitopes, suggesting a limited number of circulating antigenic variants.
Population
47 VP1 sequences of Foot-and-mouth disease virus serotype Asia1 isolates from different countries of South…
Design
Preclinical
Authors
Loading...
May inform conserved-epitope vaccines for FMDV Asia1; hypothesis-generating and requires in vivo validation before advancing.
The identification of conserved antigenic peptides in FMDV serotype Asia1 highlights the potential for developing synthetic vaccines targeted at strains circulating in South Asia.
Sultana et al. (2013) studied Foot-and-mouth disease virus (FMDV) serotype Asia1 (n=47). In-silico sequence and structural analysis was evaluated on Antigenic heterogeneities and variations at antigenic sites. In-silico analysis of 47 FMDV serotype Asia1 VP1 sequences identified five antigenic peptides as the least variable epitopes, suggesting a limited number of circulating antigenic variants.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: