Key result
Viral protein 1 (VP1) for the Asia 1 serotype of Foot and Mouth Disease Virus represented the best result as a potential peptide vaccine candidate based on in-silico analysis.
In-silico analysis identifies VP1 of the Asia 1 serotype as a promising candidate for multivalent FMDV vaccine development.
Hypothesis-generating for VP1-based FMDV vaccines; requires in vivo validation before any clinical consideration.
In this study, the capsid proteins of four major serotypes of Foot and Mouth Disease Virus (FMDV) were assessed as the vaccine candidates. Different protein sequences regarding FMDV capsid of O, A, Asia 1 and C type were identified from NCBI Genome Database and UniprotKB. Phylogenetic tree of the four serotypes was developed using ClustalW software. HMMTOP, RANKPEP, Swiss-Model and Vaxign software were used for comparing the capsid proteins in terms of their feasibility as vaccine candidates. The virus and viral serotype were identified from the cultured disease sample using RT-PCR. Our results revealed that different capsid proteins of the four serotypes vary in their suitability to be considered as peptide vaccine components. Viral protein 1 (VP1) for Asia 1 serotype represented the best result as a vaccine candidate. The VP1 region of Asia 1 serotype amplified based on the result of dry lab analysis. Our findings provide a future indication of multivalent vaccine development against FMDV.
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F M Nazmul Hassan (2015) studied Foot and Mouth Disease Virus (FMDV). Capsid proteins of FMDV (O, A, Asia 1, C type) was evaluated on Feasibility as vaccine candidates. Viral protein 1 (VP1) for the Asia 1 serotype of Foot and Mouth Disease Virus represented the best result as a potential peptide vaccine candidate based on in-silico analysis.
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