What does this research mean for the field?

Antigenic variation in foot-and-mouth disease virus (FMDV) type C over six decades is driven by fluctuations among limited combinations of amino acid residues and linear accumulation of silent mutations, rather than a continuous accumulation of amino acid substitutions. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

June 1, 1992Journal of VirologyOpen Access

Evolution of the capsid protein genes of foot-and-mouth disease virus: antigenic variation without accumulation of amino acid substitutions over six decades

View Full Paper

Ask AI

Bookmark

Population

Foot-and-mouth disease virus of serotype C isolates from Europe, South America, and The Philippines over a…

Design

Preclinical

Follow-up

6 decades (retrospective analysis of isolates)

Authors

MMMiguel Ángel Martı́nezUniversitat Autònoma de Barcelona JDJoaquı́n DopazoAndalusian Health Service JHJavier HernándezInserm

Discussion

Member takes

Implication

Supports antigenic fluctuation without net drift in FMDV; leaves open implications for sustained vaccine efficacy in livestock.

Structured PICO

Population

Foot-and-mouth disease virus (FMDV) of serotype C isolates from Europe, South America, and The Philippines over a 6-decade period

Intervention

Phylogenetic analysis of nucleotide sequences of the capsid protein-coding regions (VP1 and P1 RNAs)

Outcome

Genetic diversification and evolutionary lineages

Antigenic variation in FMDV type C over 6 decades was due to fluctuations among limited combinations of amino acid residues without net accumulation of amino acid replacements over time.

Cite This Study

Martı́nez et al. (1992) studied this question.

synapsesocial.com/papers/6a1dc6ef66df492de1601ca1 https://doi.org/10.1128/jvi.66.6.3557-3565.1992

View Full Paper

Ask AI

Bookmark

Evolution of the capsid protein genes of foot-and-mouth disease virus: antigenic variation without accumulation of amino acid substitutions over six decades

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Evolution of the capsid protein genes of foot-and-mouth disease virus: antigenic variation without accumulation of amino acid substitutions over six decades

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider