Key result
Bayesian coalescent analysis dates the FMDV most recent common ancestor to ~481 years ago.
Why the study?
The genome-wide phylogeny and molecular evolution mechanisms of foot and mouth disease virus (FMDV) were not fully defined using comprehensive sequence data.
Population
217 polyprotein coding region sequences of FMDV from GenBank
Comparison
Phylogenetic relationships among FMDV serotypes using Bayesian methods
Design
Bayesian phylogenomic and molecular evolutionary analysis
Authors
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Offers FMDV evolutionary baseline; leaves open utility for outbreak modeling and vaccine updates in livestock.
Bayesian phylogenetic analysis reveals the evolutionary rate and population dynamics of foot-and-mouth disease virus, providing insights into its molecular evolution.
Park et al. (2011) studied Foot-and-Mouth Disease Virus (n=217). Bayesian coalescent analysis was evaluated on Evolutionary rate of FMDV isolates. Bayesian coalescent analysis estimated the evolutionary rate of FMDV to be 1.46 × 10^-3 substitutions/site/year, with the most recent common ancestor existing approximately 481 years ago.
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