Why the study?
Knowledge of the molecular mechanisms underlying differences in virulence beyond multiple topotypes and serotypes was needed to aid understanding of foot-and-mouth disease virus infection.
VP1 selectivity and 3D protein replication fidelity are independent genetic determinants of FMDV virulence, which may aid in developing safe live vaccines and antivirals.
Answers are grounded in this paper and cite their sources.
May guide FMDV vaccine/antiviral design; leaves open validation in livestock outbreaks.
Efforts to understand the universal mechanism of foot-and-mouth disease virus (FMDV) infection may be aided by knowledge of the molecular mechanisms which underlie differences in virulence beyond multiple topotypes and serotypes of FMDV. Here, we demonstrated independent genetic determinants of two FMDV isolates which have different transmissibility in cattle, namely, VP1 and 3D protein. Findings suggested that the selectivity of VP1 for host cell receptors and replication fidelity during replication were important individual factors in the induction of differences in virulence in the host as well as in the severity of outbreaks in the field. These findings will aid the development of safe live vaccines and antivirals which obstruct viral infection in natural hosts.
No takes yet. Share an insight, caveat, or question.
Nishi et al. (2019) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: