Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 1975Journal of General Virology

Temperature-sensitive Mutants of Foot-and-Mouth Disease Virus: the Isolation of Mutants and Observations on their Properties and Genetic Recombination

View Full Paper
Ask AI
Bookmark
Share

Population

Two strains of foot-and-mouth disease virus (FMDV), including strain Pacheco

Design

Preclinical

Authors

JMJ. S. MackenzieThe University of Western AustraliaWSW. R. SladeThe Pirbright InstituteJLJ. R. LakeHealth Promotion Board

Discussion

Loading...

Member takes

Overview

Supports FMDV genetic mapping via recombination; extends mutant-cross techniques while leaving clinical translation open.

Structured PICO

P
Population
Two strains of foot-and-mouth disease virus (FMDV), including strain Pacheco
I
Intervention
Isolation and characterization of temperature-sensitive mutants and observation of genetic recombination
O
Outcome
Properties of mutants (growth curves, cut-off temperatures, thermal lability, pH sensitivity) and genetic recombination frequencies

The study demonstrates that genetic mapping of foot-and-mouth disease virus is possible using two- or three-factor crosses of temperature-sensitive mutants.

Cite This Study

Mackenzie et al. (1975) studied this question.

synapsesocial.com/papers/6a866c0edc090bdfff1b2fcdhttps://doi.org/10.1099/0022-1317-27-1-61
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Recombination Between Conditional Lethal Mutants Within a Strain of Foot-and-mouth Disease Virus1968 · 25 citations
  2. 2Properties of Temperature-sensitive Mutants of the KENYA 3/57 Strain of Foot-and-mouth Disease Virus1970 · 10 citations
  3. 3Improved Technique for the Isolation of Temperature-Sensitive Mutants of Foot-and-Mouth Disease Virus1973 · 14 citations
  4. 4Production of Infectious RNA and Serum-blocking Antigen by Poliovirus Temperature-sensitive Mutants1968 · 16 citations
  5. 5A Preliminary Study of Physiological Characteristics of Temperature-Sensitive Mutants of Influenza Virus1973 · 13 citations