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April 1, 1981Journal of General Virology

A Sensitive Method for the Detection and Isolation of Recombinants of Foot-and-Mouth Disease Virus

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Population

Foot-and-mouth disease (FMD) virus temperature-sensitive (ts) mutants and infected cells

Comparison

Infectious centre technique vs Conventional virus yield test

Design

Preclinical

Authors

DMD. McCahonThe Pirbright InstituteWSW. R. SladeThe Pirbright Institute

Discussion

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Implication

Increases recombinant detection in FMDV models; leaves open translation to other systems or applications.

Structured PICO

P
Population
Foot-and-mouth disease (FMD) virus temperature-sensitive (ts) mutants and infected cells
I
Intervention
Infectious centre technique (brief incubation at permissive temperature followed by assay at restrictive temperature)
C
Comparator
Conventional virus yield test
O
Outcome
Detection and isolation of recombinant plaques

A novel infectious centre technique provides a highly sensitive method for detecting and isolating recombinants of foot-and-mouth disease virus, facilitating the study of genetic interactions.

Cite This Study

McCahon et al. (1981) studied this question.

synapsesocial.com/papers/6a82f495ff6798fd267d55f1https://doi.org/10.1099/0022-1317-53-2-333
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Biochemical Mapping of the Foot-and-Mouth Disease Virus Genome1977 · 48 citations
  2. 2Temperature-sensitive mutants of foot-and-mouth disease virus with altered structural polypeptides. II. Comparison of recombination and biochemical maps1980 · 31 citations
  3. 3Temperature-sensitive Mutants of Foot-and-Mouth Disease Virus: the Isolation of Mutants and Observations on their Properties and Genetic Recombination1975 · 22 citations
  4. 4An Extended Genetic Recombination Map for Foot-and-Mouth Disease Virus1977 · 48 citations
  5. 5A Genetic Recombination Map of Foot-and-Mouth Disease Virus1975 · 34 citations