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June 1, 1975Infection and ImmunityOpen Access

Production, Isolation, and Partial Characterization of Three Foot-and-Mouth Disease Virus Temperature-Sensitive Mutants

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Population

Infant mice, guinea pigs, and steers

Comparison

Three high temperature-sensitive mutants of… vs Wild-type (wt) foot-and-mouth disease virus

Design

Preclinical

Authors

JRJonathan Y. RichmondCenters for Disease Control and Prevention

Discussion

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Overview

Animal data on temperature-sensitive FMDV mutants support attenuated vaccine development; leaves open translation to field use in susceptible species.

Structured PICO

P
Population
Infant mice, guinea pigs, and steers
I
Intervention
Three high temperature-sensitive (ts) mutants of foot-and-mouth disease virus (ts-24, ts-42, ts-22)
C
Comparator
Wild-type (wt) foot-and-mouth disease virus
O
Outcome
Ability to grow at 33 or 38.5 C, kill infant mice, infect guinea pigs, and produce foot-and-mouth disease in steerssurrogate

Temperature-sensitive mutants of foot-and-mouth disease virus show attenuated pathogenicity and potential for inducing protective immunity in animal models.

Cite This Study

Jonathan Y. Richmond (1975) studied this question.

synapsesocial.com/papers/6a8af4a33fd21775a533802fhttps://doi.org/10.1128/iai.11.6.1291-1295.1975
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Also Consider

Synapse has enriched one closely related paper. Consider it for comparative context:

  1. 1Improved Technique for the Isolation of Temperature-Sensitive Mutants of Foot-and-Mouth Disease Virus1973 · 14 citations