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July 1, 1981Proceedings of the National Academy of SciencesOpen Access

Temperature-sensitive RNA polymerase mutants of a picornavirus.

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Population

Foot-and-mouth disease virus (FMDV) mutants (ts 22 and ts 115) and baby hamster kidney cells

Comparison

Temperature-sensitive mutations in the RNA… vs Spontaneous revertants / parental proteins

Design

Preclinical

Authors

PLPeter A. LoweThe Pirbright InstituteAKAndrew M. Q. KingThe Pirbright InstituteDMD. McCahonThe Pirbright Institute

Discussion

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Overview

Temperature-sensitive FMDV polymerase mutations impair replication; leaves open attenuated vaccine strategies in livestock.

Structured PICO

P
Population
Foot-and-mouth disease virus (FMDV) mutants (ts 22 and ts 115) and baby hamster kidney cells
I
Intervention
Temperature-sensitive mutations in the RNA polymerase protein (P56a)
C
Comparator
Spontaneous revertants / parental proteins
O
Outcome
Virus RNA synthesis and RNA polymerase transcribing activity at nonpermissive temperaturessurrogate

Temperature-sensitive mutations in the FMDV RNA polymerase protein P56a severely impair viral RNA synthesis at nonpermissive temperatures.

Cite This Study

Lowe et al. (1981) studied this question.

synapsesocial.com/papers/6a82f495ff6798fd267d55f0https://doi.org/10.1073/pnas.78.7.4448
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Isolation and preliminary characterization of temperature-sensitive mutants of encephalomyocarditis virus1978 · 10 citations
  2. 2Improved Technique for the Isolation of Temperature-Sensitive Mutants of Foot-and-Mouth Disease Virus1973 · 14 citations
  3. 3Poliovirus-specific primer-dependent RNA polymerase able to copy poly(A).1977 · 179 citations
  4. 4Temperature-sensitive mutants of foot-and-mouth disease virus with altered structural polypeptides. II. Comparison of recombination and biochemical maps1980 · 31 citations
  5. 5Temperature-sensitive mutants of foot-and-mouth disease virus with altered structural polypeptides. I. Identification by electrofocusing1980 · 43 citations