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February 1, 1975Journal of VirologyOpen Access

Physiological characterization of temperature-sensitive mutants of mengovirus

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Population

L-67-S cells infected with twenty-four temperature-sensitive mutants of mengovirus

Comparison

Temperature shifts (39.5 C and 31.5 C) vs Wild-type mengovirus

Design

Preclinical

Authors

CBClifford W. BondMontana State UniversityHSH. E. SwimUniversity of Utah

Discussion

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Implication

Offers phenotypic classification for mengovirus mutants; leaves open functional validation and relevance to human pathogens.

Structured PICO

P
Population
L-67-S cells infected with twenty-four temperature-sensitive mutants of mengovirus
I
Intervention
Temperature shifts (39.5 C and 31.5 C)
C
Comparator
Wild-type mengovirus
O
Outcome
Viral RNA synthesis and phenotype characterizationsurrogate

Temperature-sensitive mutants of mengovirus can be classified into four distinct groups based on their viral RNA synthesis capabilities at different temperatures.

Cite This Study

Bond et al. (1975) studied this question.

synapsesocial.com/papers/6a8a774b6fc170cbc2fbf14dhttps://doi.org/10.1128/jvi.15.2.288-296.1975
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Also Consider

Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Identification of Poliovirus Temperature-sensitive Mutants having Defects in Virus Structural Protein1970 · 18 citations
  2. 2Replication of Mengovirus I. Effect on Synthesis of Macromolecules by Host Cell1966 · 122 citations
  3. 3Transport as the Rate-Limiting Step in the Incorporation of Uridine into Mengovirus Ribonucleic Acid in Novikoff Rat Hepatoma Cells1971 · 15 citations
  4. 4PLAQUE FORMATION AND ISOLATION OF PURE LINES WITH POLIOMYELITIS VIRUSES1954 · 3,841 citations