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July 1, 1978Journal of VirologyOpen Access

Isolation and preliminary characterization of temperature-sensitive mutants of encephalomyocarditis virus

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Population

30 temperature-sensitive mutants of encephalomyocarditis virus and infected HeLa cells

Comparison

Exposure to nonpermissive temperature vs Wild-type virions

Design

Preclinical

Authors

RRR. J. RadloffCalifornia Institute of Technology

Discussion

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Overview

Supports mechanistic research on picornavirus assembly; leaves open translation to clinical myocarditis management or antiviral development.

Structured PICO

P
Population
30 temperature-sensitive mutants of encephalomyocarditis virus and infected HeLa cells
I
Intervention
Exposure to nonpermissive temperature
C
Comparator
Wild-type virions
O
Outcome
Phenotypic characteristics including RNA synthesis, thermosensitivity, viral particle production, and precursor polypeptide cleavagesurrogate

The study characterizes temperature-sensitive mutants of encephalomyocarditis virus, revealing defects in precursor polypeptide cleavage for capsid proteins at nonpermissive temperatures.

Cite This Study

R. J. Radloff (1978) studied this question.

synapsesocial.com/papers/6a82573faedbb2834ec6ae35https://doi.org/10.1128/jvi.27.1.182-192.1978
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  5. 5Temperature-sensitive Mutants of Foot-and-Mouth Disease Virus: the Isolation of Mutants and Observations on their Properties and Genetic Recombination1975 · 22 citations