Key result
Temperature-sensitive mutants of encephalomyocarditis virus reverted most rapidly in BHK-21 cells and least rapidly in HeLa cells during serial passage.
Population
Temperature-sensitive mutants of encephalomyocarditis virus in HeLa, L929, and BHK-21 cell lines
Comparison
Serial passage vs Comparison between HeLa, L929, and BHK-21 cell…
Design
Preclinical
Authors
Loading...
Cell line-specific reversion rates warrant caution in mutant stability assumptions; leaves open host factors in EMCV evolution.
Reversion of temperature-sensitive mutants of encephalomyocarditis virus occurs at different rates depending on the host cell line, being fastest in BHK-21 and slowest in HeLa cells.
R. J. Radloff (1985) studied this question. Temperature-sensitive mutants of encephalomyocarditis virus reverted most rapidly in BHK-21 cells and least rapidly in HeLa cells during serial passage.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: