June 1, 1978The Journal of Experimental MedicineOpen Access

Isolation of a heterogeneous population of temperature-sensitive mutants of measles virus from persistently infected human lymphoblastoid cell lines.

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Population

Two human lymphoblastoid B-cell lines, WI-L2 and 8866

Design

Preclinical

Authors

GJG JuUniversity of Science and Technology of China SUStephen A. UdemPfizer (United States)BRBracha Rager‐ZismanBen-Gurion University of the Negev

Discussion

Member takes

Implication

Supports further exploration of viral mutants in persistent infections; leaves open their contribution to slow neurological diseases in humans.

Structured PICO

Population

Two human lymphoblastoid B-cell lines, WI-L2 and 8866

Intervention

Infection with the Edmonston strain of measles virus at a multiplicity of infection of 10(-6) and temperature shift to 31 degrees C

Outcome

Isolation and characterization of temperature-sensitive mutants of measles virussurrogate

Persistent measles virus infection in human lymphoblastoid cell lines leads to the generation of a heterogeneous population of temperature-sensitive mutants, which may have implications for slow neurological diseases.

Cite This Study

Ju et al. (1978) studied this question.

synapsesocial.com/papers/6a8a6c641fb56efa37d49c38 https://doi.org/10.1084/jem.147.6.1637

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Implication

Supports further exploration of viral mutants in persistent infections; leaves open their contribution to slow neurological diseases in humans.

Isolation of a heterogeneous population of temperature-sensitive mutants of measles virus from persistently infected human lymphoblastoid cell lines.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Isolation of a heterogeneous population of temperature-sensitive mutants of measles virus from persistently infected human lymphoblastoid cell lines.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider