Population
Nine temperature-sensitive (ts) mutants of nonattenuated Edmonston strain measles virus and newborn hamsters
Comparison
Temperature shift and complementation experiments vs Wild-type measles virus
Design
Preclinical
Authors
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Highlights ts measles mutants for pathogenesis studies; leaves open vaccine or attenuation potential in humans.
Temperature-sensitive mutants of the measles virus exhibit restricted intracellular infection and reduced neurovirulence compared to wild-type virus.
Bergholz et al. (1975) studied this question.
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