Population
Spontaneously transformed human lymphoid cell lines
Comparison
Exposure to attenuated and virulent types 1 and… vs Mock-infected cells
Design
Preclinical
Follow-up
up to 80 passages
Authors
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Provides in vitro model of poliovirus persistence; leaves open relevance to human chronic infection or eradication.
Poliovirus can establish persistent infection in human lymphoid cell lines, leading to the development of temperature-sensitive viral mutants.
Richard I. Carp (1981) studied this question.
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