Multiplication of Poliovirus Type I in Preparations of Human Leukocytes and Its Inhibition by Interferon

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Population

Preparations of washed human leukocytes obtained from normal blood donors

Design

Preclinical

Follow-up

up to 7-8 days

Authors

Discussion

Interferon inhibits poliovirus in human leukocytes in vitro; leaves open therapeutic translation.

Population

Preparations of washed human leukocytes obtained from normal blood donors

Intervention

Inoculation of 10^2 to 10^3 TCID50 of virulent and attenuated strains of poliovirus type I, and treatment with preparations of interferon

Outcome

Viral multiplication (measured by maximal titers in TCID50/ml) and its inhibitionsurrogate

Poliovirus type I can multiply in human leukocyte preparations, and this viral growth is inhibited by interferon.

Gresser et al. (1964) studied this question.

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