Key result
Poliovirus multiplication in the intestine induces sIgA antibodies, requiring titers of ≥1:4 for types 1 and 3, and ≥1:8 for type 2 to protect against reinfection.
Observational (n=4)
Poliovirus multiplication in the intestine induces sIgA antibodies that protect against reinfection, with the duration and amount of virus multiplication correlating with serum neutralizing antibody titers.
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Case report suggests sIgA thresholds may correlate with protection; leaves open generalizability and need for prospective validation before any clinical use.
Noriko Morimoto (2001) conducted an observational in Healthy infants receiving oral polio vaccine (n=4). Trivalent oral polio vaccine (TOPV) was evaluated on Poliovirus multiplication and sIgA antibody titers in feces. Poliovirus multiplication in the intestine induces sIgA antibodies, requiring titers of ≥1:4 for types 1 and 3, and ≥1:8 for type 2 to protect against reinfection.
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