Why the study?
Does preexisting homotypic antibody level affect the excretion of poliovirus following trivalent attenuated poliovirus vaccine in school children?
Does preexisting homotypic antibody level affect the excretion of poliovirus following trivalent attenuated poliovirus vaccine in school children?
Preexisting homotypic antibodies inversely correlate with fecal excretion of poliovirus type 1, but have less effect on types 2 and 3, following attenuated vaccine administration.
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May limit type 1 shedding after vaccination; leaves open serotype-specific effects on transmission.
Glezen et al. (1969) studied this question.
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