Why the study?
Does a three-dose primary series of trivalent oral poliovirus vaccine provide similar antibody persistence compared to a four-dose series in children at 5 years?
Population
115 children, 5 years after primary infant immunization with trivalent oral poliovirus vaccine
Comparison
Three-dose primary series of trivalent oral… vs Four-dose primary series of trivalent oral…
Design
Cohort
Follow-up
5 years
Authors
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Supports comparable 5-year antibody persistence after 3-dose versus 4-dose tOPV; hypothesis-generating and requires randomized confirmation before practice change.
Does a three-dose primary series of trivalent oral poliovirus vaccine provide similar antibody persistence compared to a four-dose series in children at 5 years?
Both three-dose and four-dose primary infant immunization schedules with trivalent oral poliovirus vaccine provide satisfactory persistence of neutralizing antibodies over a five-year period.
Krugman et al. (1977) studied this question.
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