Key result
Immunization schedules involving one or two doses of IPV followed by bOPV failed to maintain a high positive rate for poliovirus type 2-specific antibody, with rates dropping to 35.8% at 24 months in the sIPV-bOPV-bOPV group compared to 100% in the sIPV-sIPV-tOPV group.
Why the study?
Since trivalent OPV was withdrawn and an IPV and bivalent OPV sequential immunization schedule was implemented, no immune persistence data were available for this polio vaccination strategy.
Does sequential immunization with IPV and bOPV maintain long-term poliovirus-specific neutralizing antibody positivity in infants compared to schedules with tOPV?
Population
1,104 participants who had completed sequential combined IPV and OPV schedules in phase III trials
Comparison
Different polio sequential immunization schedules (IPV-IPV-tOPV vs IPV-bOPV-bOPV and IPV-IPV-bOPV)
Follow-up
Up to 48 months of age
Authors
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bOPV schedules associate with lower type 2 seropositivity at 24 months; hypothesis-generating for boosters, needing prospective confirmation.
Observational (n=1,104)
Open-label
No
Does sequential immunization with IPV and bOPV maintain long-term poliovirus-specific neutralizing antibody positivity in infants compared to schedules with tOPV?
p-value: p=<0.0001
Sequential polio immunization schedules with one or two doses of IPV followed by bOPV fail to maintain high seropositivity for type 2 poliovirus at 48 months, indicating a potential need for early booster vaccination.
Yang et al. (2023) conducted an observational in Polio immunization (n=1,104). Sequential polio immunization schedules (IPV and bOPV) vs. tOPV-containing schedules was evaluated on Poliovirus type 2-specific antibody positive rate at 24, 36, and 48 months of age (p=<0.0001). Immunization schedules involving one or two doses of IPV followed by bOPV failed to maintain a high positive rate for poliovirus type 2-specific antibody, with rates dropping to 35.8% at 24 months in the sIPV-bOPV-bOPV group compared to 100% in the sIPV-sIPV-tOPV group.
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